In this booklet you will find all the information that was already present in the earlier editions. A few hardy females will soon reach the ripe old age of 4. Scientists have created a genomewide, highresolution map of most of the inbred mouse strains used today. The laboratory mouse handbook of experimental animals usp. Download citation the laboratory mouse among animals used in. Although laboratory mice are exposed to a very different visual environment than their ancestors, studies on the eyes of inbred strains have shown no differences in retinal anatomy and visual pigment expression compared to wild mice shupe et al. Usually these animals are maintained in germfree, gnotobiotic, or. He was honored as the 1996 young investigator of the year by the american association for laboratory animal science, and in. Mouse hepatitis virus, syncytia in intestinal epithelium, mouse. Important biological features introduction mice have been domesticated for centuries, even millennia, and have been used in scientific research since the 1600s. A few of the previously published sections sexual maturity, estrous cycle, mating, and. The jackson laboratory handbook on genetically standardized mice. This is the third, revised edition of the booklet biosafety in the laboratory.
Affordable and search from millions of royalty free images, photos and vectors. The third edition of the laboratory rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. However, development of the laboratory mouse as a research model really began with genetic experiments in the early 1900s. The laboratory mouse, 2e is a comprehensive book written by international experts. Only a few alterations have been made, especially in the text concerning decontamination and inactivation. This book, part of the highly successful handbook of experimental animals series, allows the user quick access to any point of interest on the mouse as an experimental model. The mouse in biomedical research, 2nd edition volume i history, wild mice, and genetics edited by james g. With inclusions of the newly revised european standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. Successful breeding of the laboratory mouse mus musculus is critical to the establishment and maintenance of a productive animal colony.
This chapter is a partial revision of a chapter in biology of the laboratory mouse snell, 1941. Full text of biology of the laboratory mouse see other formats. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in. Show less among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. Mice that are part of an aging study at the jackson laboratory appear to have won the genetic lottery and are thought to be the oldest mice currently living in the world. The laboratory mouse crc press book mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. Labome has surveyed formal publications citing animal models to provide an overview of animal models in publications table 1. Mouse anatomy american association for laboratory animal. The anatomy of the laboratory mouse, by margaret j.
This book is available with additional data at biodiversity heritage library. Experimental techniques on rodents, carnivores, birds, ruminants and monkeys are described. Development of the laboratory mouse began with pet fanciers who bred mice for their unique coat colors. Laboratory animals, including birds, play an important role in biomedical research. Full text full text is available as a scanned copy of the original print version. The laboratory rat, second edition features updated information on a variety of topics including. Second edition continues to be the most accessible reference on the biology and care of the laboratory mouse. Substance solutions should be isotonic same tonicity as blood. Barthold center for comparative medicine schools of medicine and veterinary medicine university of california davis, ca muriel t. The humane care and management of these animals is an ongoing concern.
They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. The laboratory mouse was derived from the common house mouse, mus musculus. Pages in category laboratory mouse strains the following 18 pages are in this category, out of 18 total. The laboratory mouse is a small mammal of the order rodentia which is bred and used for scientific research. The nutrient requirements of mice have been defined by several different criteria including growth, reproduction, longevity, nutrient storage, enzyme activity, gross or histo suggested citation. Development and reproduction of the laboratory mouse. A premier source of information on the laboratory rat that will be of interest to veterinary and. Arenaviridae lymphocytic choriomeningitis virus lcmv 1. The laboratory mouse laboratory animal pocket reference. Mice and rats as laboratory animals merck veterinary manual. The discussion features an introduction to common laboratory mouse strains, including the nude mouse, whose genetic makeup renders them both hairless and immunodeficient. This wellillustrated edition offers new and updated chapters including immunology, viruses.
By 1901, william castle, the greatgrandfather of mammalian genetics, recognized the potential of mice to test mendels theories. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Featuring newly revised european standards on laboratory animals, this. Get a printable copy pdf file of the complete article 252k, or click on a page image below to browse page by page.
The laboratory mouse handbook of experimental animals. One of the most timeconsuming activities in research laboratories is looking up information specific to the species or strain of animal being used. Find specific details on this topic and related topics from the merck vet manual. Latest incidence of laboratory mice developing mouse pox due to such serum occurred in 2003. With inclusions of the newly revised european standards on. The survey results indicate that mouse is the overwhelmingly preferred laboratory animal. Intravenous injection tail vein mouse revised may 2016 1 laboratory animal biomethodology workshop u the laboratory mouse intravenous injection tail vein 1. Featuring newly revised european standards on laboratory animals, this book is the uptodate authority on the care of mice in laboratory research internationally.
There is more than one author in the goodreads database with this name. Infection of skin scratches and bite wounds with mouse or humanborne opportunistic microbes demands attention through a strict occupational medical treatment program national research council, 1997. The laboratory mouse, second edition continues to be the most accessible reference on the biology and care of the laboratory mouse. Information is provided about the anatomical features and landmarks for conducting a physical examination, collecting biological samples, making. Brown for the international committee on standardized genetic nomenclature for mice.
The laboratory mouse is the most common used mammalian research model in biomedical research. Laboratory mouse, second edition is a comprehensive book written by international experts. The golden girls of laboratory miceare these the oldest. Learn about the veterinary topic of mice and rats as laboratory animals. The merck veterinary manual was first published in 1955 as a service to the community. With inclusions of the newly revised european standards on laboratory animals, this will be the most. This book is a reference on the care and use of mice in a research setting.
Col lection of body fluids, infusion techniques, care before, during and after surgery, radiography, euthanasia and disposal, parasitic infection, germfree techniques, aerosol challenge and drug administration are covered in this volume from basic techniques to refined special procedures. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. A brief history of mouse research is also offered, ranging from their first use in genetics experiments to nobel prizewinning discoveries in immunology and neurobiology. A new addition to the acclaimed laboratory animal pocket reference series, the laboratory bird is. The laboratory mouse, second edition is a comprehensive book written by international experts. These fancy mice then became subjects for research due to interest in the mechanisms of inheritance of these coat colors. Anatomically, the mouse eye is broadly comparable to that of most other vertebrate species, with a cornea and lens that. Fox division of comparative medicine, mit cambridge, ma stephen w. The final chapter 6 provides the lists of possible sources and suppliers of additional information, animals, feed, sanitation supplies.
Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project. Connecting the reader from the mouse to the microscope, it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. Genetic variants and strains of the laboratory mouse. Important biological features hebrew university of jerusalem. This book, part of the highly successful handbook of experimental animals series, allows. Laboratory mice are usually of the species mus musculus. Laboratory animal pocket reference crc press online. Nevertheless, it was not until clarence cook little developed the first inbred mouse strain, dba, in 1909 that the modern laboratory mouse was born. Beware of mouse serum that is commercially available. Origin of the laboratory mouse and related subspecies jeanlouis guenet and francois bonhomme 3 introduction 3 the phylogenetic relationships of the house mouse 4 mouse interspecific hybridization 5 the house mouse as a laboratory model.
New and updated chapters include immunology, bacteria and parasites, behavior, enrichment and care. Revised to reflect advances since the first edition, the laboratory mouse, second edition continues to be the most accessible reference on the biology and care of the laboratory mouse. Additionally the laboratory mouse continues to play a widely publicized vital role in the. Although little scientific information on handling and restraint of mice is available, many general text books touch upon the technical approach of this topic. Order your anatomy atlas from the aalas store comparative anatomy of the mouse and rat.
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